Always know how your story ends. A story without an ending isn't a story. If you do everything right then leave your audience hanging, you will garner resentment from them, because they actually invested themselves in what you were telling them, only to be let down.
By the same token, your ending may not be conducive to what you want people to feel when you tell your story. For instance, if you're talking to a woman you want to get all hot and bothered, would you tell a story that had to do with your best friend dying or a girl you know who got raped? Of course not. You'd want to tell stories about whirlwind romances, or love at first site, or steamy rendezvous.
Knowing your outcome will also keep you on track. Too many times, you'll see people struggle to figure out where they're going with a story, or what the point of what they're saying is. They'll stutter, their tonality with get quieter, their eyes will dart around nervously as they try to think of something to say next.
All those actions will help lose your audience.
Simply by knowing what the point of your story is and how it will end will do wonders for your ability to tell it.
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This book discusses the futility of curing stammering by common means. It traces various attempts at curing stammering in the past and how wasteful these attempt were, until he discovered a simple program to cure it. The book presents the life of Benjamin Nathaniel Bogue and his struggles with the handicap. Bogue devotes a great deal of text to explain the handicap of stammering, its effects on the body and psychology of the sufferer, and its cure.